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Beta Lactamase Producing Clostridium perfringens Bacteremia in an Elderly Man with Acute Pancreatitis
Nupur Sinha,Rashmi Mishra,Richard Duncalf
- , 2016, DOI: 10.1155/2016/7078180
Abstract:
An Innocent Appearing Subcutaneous Nodule Diagnoses a Small Cell Lung Cancer in a Never-Smoker Female
Nupur Sinha,Masooma Niazi,Gilda Diaz-Fuentes,Richard Duncalf
Case Reports in Oncological Medicine , 2014, DOI: 10.1155/2014/268404
Abstract: Lung cancer among never-smokers is recognized as the 7th most common cause of cancer death globally. Adenocarcinoma is the most commonly reported histology. Small cell lung cancer (SCLC) has the strongest association with smoking and is rarely reported in never-smokers. Although lung cancer in never-smokers is more common in women, the overall incidence of SCLC in female never-smokers still remains low. Soft tissue metastases from any cancer are rare with an overall prevalence of 1.8%. Soft tissue metastases from lung primary are uncommon, mostly from adenocarcinoma, and portend a poor prognosis. Cutaneous metastases from SCLC are exceptionally rare with reported incidence of 0.3% to 0.8%. We believe ours is the first reported case of SCLC presenting as subcutaneous nodule, in a never-smoker, otherwise asymptomatic female. The diagnosis of SCLC was made incidentally by the excisional biopsy of the subcutaneous nodule. Subsequent CT chest and PET scan revealed a hypermetabolic right lower lobe spiculated lung mass with adrenal and liver involvement. Platinum and etoposide chemotherapy with prophylactic cranial irradiation was initiated for advanced SCLC, and she required further irinotecan and taxol for subsequent pancreatic and adrenal metastases. With continued deterioration, she died approximately 36 months from diagnosis, while under hospice care. 1. Introduction Lung cancer in never-smokers is increasingly being recognized as a distinct entity and ranks as the seventh most common cause of cancer death globally [1, 2]. Worldwide, 15% of men and 53% of women with lung cancer are never-smokers [2]. Adenocarcinoma is the most commonly reported histology in never-smokers [1, 2]. Recognized as an entity distinct from other lung cancers in 1926 by Dr. W. G. Bernard, small cell lung cancer (SCLC) accounts for 15% of annual lung cancers in the USA and is known to have the strongest association with tobacco use. More than 95% occur in smokers, with 95% fatality [3]. Small cell lung cancer in never-smokers is rarely reported. Soft tissue metastases from lung cancer are uncommon with reported overall prevalence of 2.3% [4], and rarely reported from SCLC. We report the first case of SCLC in a never-smoker woman presenting as subcutaneous nodule. 2. Case Presentation A 54-year-old woman presented with a two-month history of an enlarging, slightly painful left flank nodule. There was no preceding history of trauma or insect bite to the involved region. She denied fever, chills, rash, cough, shortness of breath, hemoptysis, mouth ulcers, arthralgias, dysuria, or
Diels-Alder Cycloaddition of Cyclopentadiene to a Bis-naphthoquinone
Margaret A. Brimble,Letecia J. Duncalf
Molecules , 2000, DOI: 10.3390/50200162
Abstract: Addition of cyclopentadiene to bis-naphthoquinone (1) afforded predominantly the endo-endo [4+2] cycloadduct (2).
PNUTS/PP1 Regulates RNAPII-Mediated Gene Expression and Is Necessary for Developmental Growth
Anita Ciurciu,Louise Duncalf,Vincent Jonchere,Nick Lansdale,Olga Vasieva,Peter Glenday,Andreii Rudenko,Emese Vissi,Neville Cobbe,Luke Alphey,Daimark Bennett
PLOS Genetics , 2013, DOI: 10.1371/journal.pgen.1003885
Abstract: In multicellular organisms, tight regulation of gene expression ensures appropriate tissue and organismal growth throughout development. Reversible phosphorylation of the RNA Polymerase II (RNAPII) C-terminal domain (CTD) is critical for the regulation of gene expression states, but how phosphorylation is actively modified in a developmental context remains poorly understood. Protein phosphatase 1 (PP1) is one of several enzymes that has been reported to dephosphorylate the RNAPII CTD. However, PP1's contribution to transcriptional regulation during animal development and the mechanisms by which its activity is targeted to RNAPII have not been fully elucidated. Here we show that the Drosophila orthologue of the PP1 Nuclear Targeting Subunit (dPNUTS) is essential for organismal development and is cell autonomously required for growth of developing tissues. The function of dPNUTS in tissue development depends on its binding to PP1, which we show is targeted by dPNUTS to RNAPII at many active sites of transcription on chromosomes. Loss of dPNUTS function or specific disruption of its ability to bind PP1 results in hyperphosphorylation of the RNAPII CTD in whole animal extracts and on chromosomes. Consistent with dPNUTS being a global transcriptional regulator, we find that loss of dPNUTS function affects the expression of the majority of genes in developing 1st instar larvae, including those that promote proliferative growth. Together, these findings shed light on the in vivo role of the PNUTS-PP1 holoenzyme and its contribution to the control of gene expression during early Drosophila development.
On the Prevention of Obesity and a Philosophy for Healthy Living  [PDF]
Richard Visser
Food and Nutrition Sciences (FNS) , 2012, DOI: 10.4236/fns.2012.37128
Abstract: Overweight and obesity have now reached historical, maximal peak values, with nearly one-third of world population suffering from these conditions. We are now witnessing the impact of this epidemic upon the global health status, with non-communicable diseases on the rise. We have also witnessed the shortcomings and failures of past actions taken when obesity is already present. In this essay the author reviews efforts made in the past regarding identification and treatment of obesity, and propose that actions should be taken before the onset of this disease, by motivating people to make intelligent, healthy choices when it comes to food and physical activity. A philosophy for healthy living should become central to the intervention actions, for them to be successful and sustained. Prevention of obesity should involve all those concerned irregardless of their position in society and curricular training, in order to create a multi-lateral, multi-national effort that will protect our families and our children from the consequences of this epidemic.
A Supportive Approach to Supervising Students Reading for a Phd in Systems and Software Engineering  [PDF]
Richard Lai
Creative Education (CE) , 2012, DOI: 10.4236/ce.2012.326138
Abstract: Supervising a PhD student is a complex teaching task as it involves a very unstructured environment and many intellectual challenges and stimuli, and it often requires a compatible student/supervisor relationship for successful outcomes. It is therefore not surprising that it has been reported that an aspect of teaching and learning that has been overlooked in higher education is research student supervision. Typical problems of poor supervision include: high rates of dissatisfaction with supervisors and high attrition rates and slow rates of completion for students. It has also been reported that there is no set prescription on appropriate and successful supervision; rather, the interactions between quality and style of supervision, and the field of study have all to be considered. It is not easy to know what a student and his/her supervisor should be doing in order to succeed. We are thus motivated to present in this paper our approach to supervising students reading for a PhD in systems and software engineering. This approach is centered on motivating students to learn and to do research by having supervisory activities that support their development throughout their candidature.
The Evolution of Curriculum Development in the Context of Increasing Social and Environmental Complexity  [PDF]
Richard Plate
Creative Education (CE) , 2012, DOI: 10.4236/ce.2012.38192
Abstract: The history of curriculum development has been characterized and a series of “crises” with the pendulum shifting between traditionalists’ call for getting back to the basics and the progressives’ focus on the learner. However, tracing this history, one can see a common theme in the criticisms expressed by both parties: the failure of the existing curriculum to meet the demands presented by an increasingly complex society. I follow this theme in order to provide historical context for contemporary calls by scientists and educators for wider use of systems-oriented curricula (i.e. curricula designed to improve systems thinking) at primary, secondary, and tertiary levels of education. With this context, one can view these current calls not as a radical shift of direction, but as a logical next stage in the evolution of curriculum. I conclude with a call for more research assessing the effectiveness of systems-oriented instruction and provide guidelines for enhancing the usefulness of such research in the current United States system.
Sino-French Engineering Curriculums: An Ongoing Process for Elitist Education?  [PDF]
Richard Mariom
Creative Education (CE) , 2012, DOI: 10.4236/ce.2012.37B048
Abstract: Here is a multisite case-study paper presenting Sino-French engineering education reform cooperation process. This questions the consequences for the introduction of a hybrid framework in a both dynamic and dichotomous innovation context such as Chinese one.
Kant’s Emergence and Sellarsian Cognitive Science  [PDF]
Richard McDonough
Open Journal of Philosophy (OJPP) , 2014, DOI: 10.4236/ojpp.2014.41007
Abstract:

The paper argues, against current views that see Kant as giving abstract descriptions of cognitive mechanisms (after the fashion of functionalism in cognitive science), that Kant sees mental phenomena as akin to emergent phenomena in a sense traditionally opposed to mechanism. After distinguishing several relevant notions of emergence, the paper distinguishes several of Kant’s basic emergentist theses, including his emergent materialism in chemistry and a species of mental emergence modelled on that chemical emergence. However, Kant’s doctrine of the epigenesis of pure Reason is argued to be Kant’s most fundamental emergentist thesis. The paper argues that Kant’s notion of mental emergence sheds light on some very puzzling aspects of his remarks about the unity of intuition and concept emphasized by Wilfrid Sellars. The paper sketches some of the problems in contemporary cognitive science and shows how a Sellarsian emergentism inspired by Kant addresses some of these problems and provides an interesting alternative to the kind of mechanistic positions that have tended to dominate the field. Finally, the paper locates the present emergentist reading with respect to the perspectivist reading of Kant.

A phenomenological 10-dimension space-time model  [PDF]
Richard Bonneville
Natural Science (NS) , 2014, DOI: 10.4236/ns.2014.64025
Abstract:

The possibility of a description of the fundamental interactions of physics, including gravitation, based upon the assumption of 6 real extra dimensions is presented. The usual 4-dimension space-time, a curved surface with the Lorentz group as local symmetry, is embedded in a larger flat 10-dimension space. Through a fundamental assumption about the geometry of the orthogonal 6-d space in every point of the 4-d surface, there are two possibilities for classifying the physical states, corresponding to two types of particles: 1) hadrons, experiencing a gauge field associated to a real symmetry group GH(6), isomorphous to SU(3), which is identified with the strong interaction, and 2) leptons experiencing another gauge field associated with a real symmetry group GL(6), isomorphous to SU(2) × U(1) but different from the usual electroweak coupling. In addition, both hadrons and leptons are subject to weak and electromagnetic interactions plus a scalar BEH-like coupling, with the respective real symmetries SO(3), SO(2), SO(1), isomorphous to SU(2), U(1), I(1). This description can be extended so as to include gravitation; postulating a minimal Lagrangian in the full 10-d space, the equations of motion are derived. They imply the existence of a set of additional vector-type fields which do not act the same way upon hadrons and leptons, thus inducing a violation of the equivalence principle.

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